%PDF-1.6
%
1 0 obj
<<
/Metadata 2 0 R
/Pages 3 0 R
/Type /Catalog
>>
endobj
4 0 obj
<<
/CreationDate (D:20060519071918-01'00')
/Creator (pdftk 1.12 - www.pdftk.com)
/Producer (itext-paulo \(lowagie.com\)[JDK1.1] - build 132)
/ModDate (D:20060519105454+02'00')
/Subject (It is generally agreed that the cerebral cortex can be segregated into structurally and functionally distinct areas. Anatomical subdivision of Broca's area has been achieved using different microanatomical criteria, such as cytoarchitecture and distribution of neuroreceptors. However, brain function also strongly depends upon anatomical connectivity, which therefore forms a sensible criterion for the functio-anatomical segregation of cortical areas. Diffusion-weighted magnetic resonance \(MR\) imaging offers the opportunity to apply this criterion in the individual living subject. Probabilistic tractographic methods provide excellent means to extract the connectivity signatures from diffusion-weighting MR data sets. The correlations among these signatures may then be used by an automatic clustering method to identify cortical regions with mutually distinct and internally coherent connectivity. We made use of this principle to parcellate Broca's area. As it turned out, 3 subregions are discernible that were identified as putative Brodmann area \(BA\) 44, BA45, and the deep frontal operculum. These results are discussed in the light of previous evidence from other methods in both human and nonhuman primates. We conclude that plausible results can be achieved by the proposed technique, which cannot be obtained by any other method in vivo. For the first time, there is a possibility to investigate the anatomical subdivision of Broca's area noninvasively in the individual living human subject.)
/Author <412E20416E77616E64657220616E64204D2E205469747467656D6579657220616E6420442E20592E20766F6E204372616D6F6E20616E6420412E20442E204672696564657269636920616E6420542E20522E204B6EF673636865>
/bibtex#2Fbibtexkey (Anwander_CerebCortex_preprint_2007)
/bibtex#2Fcomment (hallo jan 16:30)
/bibtex#2Fdoi (10.1093/cercor/bhk034)
/bibtex#2Ffile (Anwander_CerebCortex_preprint_2007.pdf:Anwander_CerebCortex_preprint_2007.pdf:PDF)
/bibtex#2Finstitution (Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.)
/bibtex#2Fjournal (Cereb Cortex)
/Keywords (Adult; Female; Frontal Lobe, anatomy /&/ histology; Humans; Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated, ultrastructure; Nerve Net, anatomy /&/ histology; Neural Pathways, anatomy /&/ histology)
/bibtex#2Flanguage (eng)
/bibtex#2Fmonth (Apr)
/bibtex#2Fnumber (4)
/bibtex#2Fowner (anwander)
/bibtex#2Fpages (816--825)
/bibtex#2Ftimestamp (2009.12.04)
/Title (Connectivity-Based Parcellation of Broca's Area.)
/bibtex#2Furl (http://dx.doi.org/10.1093/cercor/bhk034)
/bibtex#2Fvolume (17)
/bibtex#2Fyear (2007)
/bibtex#2Fentrytype (Article)
>>
endobj
2 0 obj
<<
/Type /Metadata
/Subtype /XML
/Length 5 0 R
>>
stream
2006-05-19T07:19:18-01:00
pdftk 1.12 - www.pdftk.com
2006-05-19T10:54:54+02:00
2006-05-19T10:54:54+02:00
itext-paulo (lowagie.com)[JDK1.1] - build 132
uuid:c5761805-701d-4aa3-8994-cc893972178e
uuid:c77c1aef-a6e4-48e7-aeb0-8ab7eba952fd
It is generally agreed that the cerebral cortex can be segregated into structurally and functionally distinct areas. Anatomical subdivision of Broca's area has been achieved using different microanatomical criteria, such as cytoarchitecture and distribution of neuroreceptors. However, brain function also strongly depends upon anatomical connectivity, which therefore forms a sensible criterion for the functio-anatomical segregation of cortical areas. Diffusion-weighted magnetic resonance (MR) imaging offers the opportunity to apply this criterion in the individual living subject. Probabilistic tractographic methods provide excellent means to extract the connectivity signatures from diffusion-weighting MR data sets. The correlations among these signatures may then be used by an automatic clustering method to identify cortical regions with mutually distinct and internally coherent connectivity. We made use of this principle to parcellate Broca's area. As it turned out, 3 subregions are discernible that were identified as putative Brodmann area (BA) 44, BA45, and the deep frontal operculum. These results are discussed in the light of previous evidence from other methods in both human and nonhuman primates. We conclude that plausible results can be achieved by the proposed technique, which cannot be obtained by any other method in vivo. For the first time, there is a possibility to investigate the anatomical subdivision of Broca's area noninvasively in the individual living human subject.
A. Anwander
M. Tittgemeyer
D. Y. von Cramon
A. D. Friederici
T. R. Knösche
bibtex/bibtexkey/Anwander_CerebCortex_preprint_2007
bibtex/comment/hallo jan 16:30
bibtex/file/Anwander_CerebCortex_preprint_2007.pdf:Anwander_CerebCortex_preprint_2007.pdf:PDF
bibtex/institution/Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
bibtex/journal/Cereb Cortex
bibtex/language/eng
bibtex/number/4
bibtex/owner/anwander
bibtex/pages/816--825
bibtex/timestamp/2009.12.04
bibtex/url/http://dx.doi.org/10.1093/cercor/bhk034
bibtex/volume/17
10.1093/cercor/bhk034
Adult; Female; Frontal Lobe
anatomy /&/ histology; Humans; Magnetic Resonance Imaging; Male; Nerve Fibers
Myelinated
ultrastructure; Nerve Net
anatomy /&/ histology; Neural Pathways
anatomy /&/ histology
Connectivity-Based Parcellation of Broca's Area.
2007-04
application/pdf
Article
A. Anwander
M. Tittgemeyer
D. Y. von Cramon
A. D. Friederici
T. R. Knösche
Anwander_CerebCortex_preprint_2007
hallo jan 16:30
10.1093/cercor/bhk034
Anwander_CerebCortex_preprint_2007.pdf:Anwander_CerebCortex_preprint_2007.pdf:PDF
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Cereb Cortex
Adult; Female; Frontal Lobe, anatomy /&/ histology; Humans; Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated, ultrastructure; Nerve Net, anatomy /&/ histology; Neural Pathways, anatomy /&/ histology
eng
Apr
4
anwander
816--825
2009.12.04
Connectivity-Based Parcellation of Broca's Area.
http://dx.doi.org/10.1093/cercor/bhk034
17
2007
Article
endstream
endobj
3 0 obj
<<
/Count 33
/Type /Pages
/Kids [6 0 R 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R
16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R
26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R
36 0 R 37 0 R 38 0 R]
>>
endobj
5 0 obj
7454
endobj
6 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents [39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R]
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 47 0 R
/Type /Page
>>
endobj
7 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 48 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 49 0 R
/Type /Page
>>
endobj
8 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 50 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 51 0 R
/Type /Page
>>
endobj
9 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 52 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 53 0 R
/Type /Page
>>
endobj
10 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 54 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 55 0 R
/Type /Page
>>
endobj
11 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 56 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 57 0 R
/Type /Page
>>
endobj
12 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 58 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 59 0 R
/Type /Page
>>
endobj
13 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 60 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 61 0 R
/Type /Page
>>
endobj
14 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 62 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 63 0 R
/Type /Page
>>
endobj
15 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 64 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 65 0 R
/Type /Page
>>
endobj
16 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 66 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 67 0 R
/Type /Page
>>
endobj
17 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 68 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 69 0 R
/Type /Page
>>
endobj
18 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 70 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 71 0 R
/Type /Page
>>
endobj
19 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 72 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 73 0 R
/Type /Page
>>
endobj
20 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 74 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 75 0 R
/Type /Page
>>
endobj
21 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 76 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 77 0 R
/Type /Page
>>
endobj
22 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 78 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 79 0 R
/Type /Page
>>
endobj
23 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 80 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 81 0 R
/Type /Page
>>
endobj
24 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 82 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 83 0 R
/Type /Page
>>
endobj
25 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 84 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 85 0 R
/Type /Page
>>
endobj
26 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 86 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 87 0 R
/Type /Page
>>
endobj
27 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 88 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 89 0 R
/Type /Page
>>
endobj
28 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 90 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 91 0 R
/Type /Page
>>
endobj
29 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 92 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 93 0 R
/Type /Page
>>
endobj
30 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 94 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 95 0 R
/Type /Page
>>
endobj
31 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 96 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 97 0 R
/Type /Page
>>
endobj
32 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 98 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 99 0 R
/Type /Page
>>
endobj
33 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 100 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 101 0 R
/Type /Page
>>
endobj
34 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 102 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 103 0 R
/Type /Page
>>
endobj
35 0 obj
<<
/CropBox [0 0 596.950012207 844.7399902344]
/Parent 3 0 R
/Contents 104 0 R
/Rotate 0
/MediaBox [0 0 596.950012207 844.7399902344]
/Resources 105 0 R
/Type /Page
>>
endobj
36 0 obj
<<
/CropBox [0 0 594.9600219727 841.9199829102]
/Parent 3 0 R
/Contents 106 0 R
/Rotate 0
/MediaBox [0 0 594.9600219727 841.9199829102]
/Resources 107 0 R
/Type /Page
>>
endobj
37 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 108 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 109 0 R
/Type /Page
>>
endobj
38 0 obj
<<
/CropBox [0 0 595 842]
/Parent 3 0 R
/Contents 110 0 R
/Rotate 0
/MediaBox [0 0 595 842]
/Resources 111 0 R
/Type /Page
>>
endobj
39 0 obj
<<
/Length 112 0 R
/Filter /FlateDecode
>>
stream
HOO0>nH
IۤqpfbCh@OibГzI{5y-ښ\n(m-6oyO|/A%ʟ]Q팺.+3YLDsP0i|Ӹk|ҸH_4k\(cU7`%,`t `XZpb=c n&.gQ(F˱&ۈN^)ɫE+8o( vdž:lTm#Vu)[!?}1ό~ 8
endstream
endobj
40 0 obj
<<
/Length 113 0 R
/Filter /FlateDecode
>>
stream
HAK@+QnwD&MH[mSwCv |73&@iJXZ.?BƽIFcqkZs⤌~gc.sLU`Ma3l'{KSwo4N(V-oP̵Ɩi55,1{7ŀwA
!ϼɧqSg*P