Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of 
cytochrome P450-catalyzed formation of the lactone ring present in 
sesquiterpene lactones of chicory

Kraker, De; Franssen, M. C. R.; Joerink, M.; De Groot, A.; Bouwmeester, H. J.

doi:10.1104/pp.010957

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Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome P450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory

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Kraker, De
Department of Biochemistry, Prof. J. Gershenzon, MPI for Chemical Ecology, Max Planck Society;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155889/
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Citation

Kraker, D., Franssen, M. C. R., Joerink, M., De Groot, A., & Bouwmeester, H. J. (2002). Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome P450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory. Plant Physiology, 129(1), 257-268. doi:10.1104/pp.010957.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-A53B-8

Abstract

Chicory (Cichorium intybus) is known to contain guaianolides, eudesmanolides, and germacranolides. These sesquiterpene lactones are postulated to originate from a common germacranolide, namely (+)-costunolide. Whereas a pathway for the formation of germ