Oxidation of linoleic acid in low-density lipoprotein: An important event in 
atherogenesis

Spiteller, D.; Spiteller, G.

doi:10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-G

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Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis

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Spiteller, D.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Spiteller, D., & Spiteller, G. (2000). Oxidation of linoleic acid in low-density lipoprotein: An important event in atherogenesis. Angewandte Chemie International Edition, 39(3), 585-589. doi:10.1002/(SICI)1521-3773(20000204)39:3<585:AID-ANIE585>3.0.CO;2-G.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-A398-6

Abstract

Contrary to earlier views the main oxidation products of low-density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as 1 and 2 have been identified for the first time, is obtained from minimally oxidized (that is, aged) LDL. Since this is still recognized by the LDL receptor, it is concluded that toxic oxidation products are introduced in endothelial cells in vivo and cause damage there