Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster 
from the marine isolate 'Streptomyces maritimus': evidence for the derailment 
of an aromatic polyketide synthase

Piel, J.; Hertweck, C.; Shipley, P. R.; Hunt, D. M.; Newman, M. S.; Moore, B. S.

doi:10.1016/s1074-5521(00)00044-2

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Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase

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Piel, J.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Hertweck, C.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Citation

Piel, J., Hertweck, C., Shipley, P. R., Hunt, D. M., Newman, M. S., & Moore, B. S. (2000). Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. Chemistry & Biology, 7(12), 943-955. doi:10.1016/s1074-5521(00)00044-2.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-A27F-A

Abstract

Background: Polycyclic aromatic polyketides, such as the tetracyclines and anthracyclines, are synthesized by bacterial aromatic polyketide synthases (PKSs). Such PKSs contain a single set of iteratively used individual proteins for the construction of