Incorporation of fluoroacetate into an aromatic polyketide and its influence on 
the mode of cyclization

Hong, H.; Spiteller, D.; Spencer, J. B.

doi:10.1002/anie.200801100

Item

ITEM ACTIONSEXPORT

Add to Basket

Please note that a newer version of this item is available:
https://pure.mpg.de/pubman/item/item_438257_6

DetailsSummary

Released

Journal Article

Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization

MPS-Authors

/persons/resource/persons4189

Spiteller, D.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Hong, H., Spiteller, D., & Spencer, J. B. (2008). Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization. Angewandte Chemie International Edition, 47(32), 6028-6032. doi:10.1002/anie.200801100.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-A0D5-3

Abstract

Fluorine, changing course: Challenging the actinorhodin minimal polyketide synthase (act‐minimal PKS) with fluoroacetyl‐CoA as a starter unit yielded a fluorinated octaketide intermediate that led to the selective formation of fluoro‐SEK4b (see scheme); no fluoro‐SEK4 was formed(not shown).