Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene 
indole alkaloid biosynthesis

Franke, Jakob; Kim, Jeongwoon; Hamilton, John P.; Zhao, Dongyan; Pham, Gina M.; Wiegert-Rininger, Krystle; Crisovan, Emily; Newton, Linsey; Vaillancourt, Brieanne; Tatsis, Evangelos; Buell, C. Robin; O'Connor, Sarah E.

doi:10.1002/cbic.201800592

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Franke, J., Kim, J., Hamilton, J. P., Zhao, D., Pham, G. M., Wiegert-Rininger, K., Crisovan, E., Newton, L., Vaillancourt, B., Tatsis, E., Buell, C. R., & O'Connor, S. E. (2019). Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis. Chembiochem, 20(1), 83-87. doi:10.1002/cbic.201800592.

引用: https://hdl.handle.net/21.11116/0000-0002-D8AF-6

要旨

Genome mining is a routine technique in microbes for discovering biosynthetic pathways. In plants, however, genomic information
is not commonly used to identify novel biosynthesis
genes. Here, we present the genome of the medicinal plant
and oxindole monoterpene indole alkaloid (MIA) producer Gelsemium
sempervirens (Gelsemiaceae). A gene cluster from Catharanthus
roseus, which is utilized at least six enzymatic steps
downstream from the last common intermediate shared between
the two plant alkaloid types, is found in G. sempervirens,
although the corresponding enzymes act on entirely different
substrates. This study provides insights into the common genomic
context of MIA pathways and is an important milestone
in the further elucidation of the Gelsemium oxindole alkaloid pathway.