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Journal Article

Two antiproliferative seco-4,5-abietane diterpenoids from roots of Salvia ceratophylla L.

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Chandran,  Jima N.
Research Group Biosynthesis / NMR, MPI for Chemical Ecology, Max Planck Society;

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Schneider,  Bernd
Research Group Biosynthesis / NMR, MPI for Chemical Ecology, Max Planck Society;

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Citation

Mirzaei, H. H., Firuzi, O., Chandran, J. N., Schneider, B., & Jassbi, A. R. (2019). Two antiproliferative seco-4,5-abietane diterpenoids from roots of Salvia ceratophylla L. Phytochemistry Letters, 29, 129-133. doi:10.1016/j.phytol.2018.11.017.


Cite as: https://hdl.handle.net/21.11116/0000-0002-B449-1
Abstract
Two previously undescribed rearranged abietanes, ceratol (1) and ceratodiol (2), and three known abietanediterpenoids,
including 1-ketoaethiopinone (3), ferruginol (4) and 12-deoxysalvipisone (5), were isolated from
roots of Salvia ceratophylla. The structures of the purified compounds (1–5) were characterized based on analyses
of their spectroscopic data, including 1D and 2D NMR and high-resolution electrospray mass spectra. The
analytical data were then compared with those reported in the literature. Cytotoxicity of the isolated compounds
was examined against two human cancer cell lines, MOLT-4 (human lymphoblastic leukemia) and MCF-7
(human breast adenocarcinoma), using the MTT reduction assay. Whereas compound 2 showed cytotoxicity
against both cancer cells, 1 showed weak toxicity against MOLT-4 cells and no toxicity against MCF-7 cells.
Compound 3 and compound 5, both of which had an α, β-unsaturated carbonyl function, showed the highest
cytotoxic activities among the tested compounds.