Biocatalytic production of tetrahydroisoquinolines

Ruff, Bettina M.; Braese, S.; O'Connor, Sarah E.

doi:10.1016/j.tetlet.2011.12.089

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Biocatalytic production of tetrahydroisoquinolines

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Ruff, B. M., Braese, S., & O'Connor, S. E. (2012). Biocatalytic production of tetrahydroisoquinolines. Tetrahedron Letters, 53(9), 1071-1074. doi:10.1016/j.tetlet.2011.12.089.

Cite as: https://hdl.handle.net/21.11116/0000-0002-B23F-F

Abstract

The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids. (C) 2012 Elsevier Ltd. All rights reserved.