Selective reduction by dopamine of excitatory synaptic inputs to pyramidal 
neurons in primate prefrontal cortex

Urban, Nathaniel N.; González−Burgos, Guillermo R.; Henze, Darrell A.; Lewis, David A.; Barrionuevo, German

doi:10.1113/jphysiol.2001.015024

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Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex

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Urban, Nathaniel N.
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Urban, N. N., González−Burgos, G. R., Henze, D. A., Lewis, D. A., & Barrionuevo, G. (2002). Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex. The Journal of Physiology - London, 539(3), 707-712. doi:10.1113/jphysiol.2001.015024.

Cite as: https://hdl.handle.net/21.11116/0000-0002-14E2-8

Abstract

We have employed in vitro physiological methods to investigate dopaminergic modulation of excitatory synaptic transmission in monkey prefrontal cortex (PFC) circuits. We show that combined activation of D1-like and D2-like dopamine receptors results in the reduction of extracellular stimulation-evoked isolated EPSCs in layer 3 pyramidal neurons. Using paired recordings from synaptically connected pyramidal neurons we have determined the basic properties of unitary synaptic connections between layer 3 pyramids in the primate PFC and, interestingly, we found that dopamine does not reduce synaptic transmission between nearby pairs of synaptically coupled PFC pyramidal neurons. This input specificity may be a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC.