English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  DetailsSummary

Released
Journal Article

Lipidome Evolution in Mammalian Tissues

MPS-Authors
/persons/resource/persons72783

Khaitovich,  Philipp
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Khrameeva, E., Kurochkin, I., Bozek, K., Giavalisco, P., & Khaitovich, P. (2018). Lipidome Evolution in Mammalian Tissues. Molecular Biology and Evolution, 35(8), 1947-1957. doi:10.1093/molbev/msy097.


Cite as: https://hdl.handle.net/21.11116/0000-0001-F6C1-F
Abstract
Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes’ sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders.