Cell permeable fluorescent dye

Umezawa, K.; Lukinavicius, G.; Johnsson, K.

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Cell permeable fluorescent dye

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Lukinavicius, G.
Laboratory of Chromatin Labeling and Imaging, Max Planck Institute for Biophysical Chemistry, Max Planck Society;

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Citation

Umezawa, K., Lukinavicius, G., & Johnsson, K.(2013). Cell permeable fluorescent dye.

Cite as: https://hdl.handle.net/21.11116/0000-0001-ECB4-A

Abstract

The invention pertains to a near-infrared fluorescent dye that is cell permeable and can be attached to selected proteins in living cells. The dye has the general formula (I) or its or its corresponding spirolactone (II) wherein Y is chosen from the group consisting of Si, Ge and Sn; R0 is -COO- or COOH; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are substituents, including hydrogen, independently from each other. The dye (i) absorbs and emits light at wavelengths above 600 nm; (ii) possesses high photostability; (iii) has high extinction coefficients and high quantum yields; (iv) can be derivatized with different molecules; and (v) is membrane-permeable and shows mini¬ mal background binding to biomolecules and biomolecular structures.