New S-adenosyl-L-methionine analogs with extended activated groups for transfer 
by methyltransferases

Weinhold, E.; Dalhoff, S.; Klimasauskas, S.; Lukinavicius, G.

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New S-adenosyl-L-methionine analogs with extended activated groups for transfer by methyltransferases

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Lukinavicius, G.
Laboratory of Chromatin Labeling and Imaging, Max Planck Institute for Biophysical Chemistry, Max Planck Society;

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Weinhold, E., Dalhoff, S., Klimasauskas, S., & Lukinavicius, G.(2006). New S-adenosyl-L-methionine analogs with extended activated groups for transfer by methyltransferases.

Cite as: https://hdl.handle.net/21.11116/0000-0001-EC8E-6

Abstract

S-Adenosyl-L-methionine analogs of formula (I) wherein R comprises a carbon-carbon double bond, carbon-oxygen double bond, carbon-sulfur double bond, carbon-nitrogen double bond, a carbon-carbon triple bond, carbon-nitrogen triple bond or an aromatic carbocyclic or heterocyclic system in ß-position to the sulfonium center, X- is an organic or inorganic anion carrying one or more negative charges, Z is -CR1R2-, -O-, -S- or -NR3- and R1, R2 and R3 are independently selected from H, D and C1-C12alkyl.