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Journal Article

Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases.

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Lukinavicius, G.
Laboratory of Chromatin Labeling and Imaging, Max Planck Institute for Biophysical Chemistry, Max Planck Society;

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Citation

Dalhoff, C., Lukinavicius, G., Klimašauskas, S., & Weinhold, E. (2006). Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases. Nature Chemical Biology, 2, 31-32. doi:10.1038/nchembio754.

Abstract

S-Adenosyl-L-methionine (AdoMet) is the major methyl donor for biological methylation reactions catalyzed by methyltransferases. We report the first chemical synthesis of AdoMet analogs with extended carbon chains replacing the methyl group and their evaluation as cofactors for all three classes of DNA methyltransferases. Extended groups containing a double or triple bond in the β position to the sulfonium center were transferred onto DNA in a catalytic and sequence-specific manner, demonstrating a high utility of such synthetic cofactors for targeted functionalization of biopolymers.