Unraveling the Complex Interplay Between T Cell Metabolism and Function

Klein Geltink, Ramon I.; Kyle, Ryan L.; Pearce, Erika L.

doi:10.1146/annurev-immunol-042617-053019

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Bitte beachten Sie, dass eine neuere Version dieses Datensatzes verfügbar ist:
https://pure.mpg.de/pubman/item/item_2623819_4

DetailsÜbersicht

Freigegeben

Zeitschriftenartikel

Unraveling the Complex Interplay Between T Cell Metabolism and Function

MPG-Autoren

Klein Geltink, Ramon I.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Kyle, Ryan L.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Pearce, Erika L.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Externe Ressourcen

Es sind keine externen Ressourcen hinterlegt

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

Es sind keine frei zugänglichen Volltexte in PuRe verfügbar

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

Klein Geltink, R. I., Kyle, R. L., & Pearce, E. L. (2018). Unraveling the Complex Interplay Between T Cell Metabolism and Function. Annual Reviews of Immunology, 36, 461-488. doi:10.1146/annurev-immunol-042617-053019.

Zitierlink: https://hdl.handle.net/21.11116/0000-0001-F66E-F

Zusammenfassung

Metabolism drives function, on both an organismal and a cellular level. In T cell biology, metabolic remodeling is intrinsically linked to cellular development, activation, function, differentiation, and survival. After naive T cells are activated, increased demands for metabolic currency in the form of ATP, as well as biomass for cell growth, proliferation, and the production of effector molecules, are met by rewiring cellular metabolism. Consequently, pharmacological strategies are being developed to perturb or enhance selective metabolic processes that are skewed in immune-related pathologies. Here we review the most recent advances describing the metabolic changes that occur during the T cell lifecycle. We discuss how T cell metabolism can have profound effects on health and disease and where it might be a promising target to treat a variety of pathologies.