Brain organoids as models to study human neocortex development and evolution

Heide, Michael; Huttner, Wieland B; Mora-Bermúdez, Felipe

doi:10.1016/j.ceb.2018.06.006

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Brain organoids as models to study human neocortex development and evolution

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Mora-Bermúdez, Felipe
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Citation

Heide, M., Huttner, W. B., & Mora-Bermúdez, F. (2018). Brain organoids as models to study human neocortex development and evolution. Current Opinion in Cell Biology, 55, 8-16. doi:10.1016/j.ceb.2018.06.006.

Cite as: https://hdl.handle.net/21.11116/0000-0001-B462-5

Abstract

Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting with a technical comparison between pre-patterning and self-patterning brain organoid protocols. We then follow neocortex development in space and time and list those aspects where organoids have succeeded in emulating in vivo development, as well as those aspects that continue to be pending tasks. Finally, we present a summary of medical and evolutionary insight made possible by organoid technology.