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Meeting Abstract

MRI-guided robotic arm (MgRA) drives optogenetic activation of the rat corpus callosum

MPS-Authors
/persons/resource/persons214924

Chen,  Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214931

Pais Roldan,  P
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214920

Chen,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu,  X
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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(Abstract)

https://www.ismrm.org/18/ToC.pdf
(Abstract)

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Citation

Chen, Y., Pais Roldan, P., Chen, X., & Yu, X. (2018). MRI-guided robotic arm (MgRA) drives optogenetic activation of the rat corpus callosum. In Joint Annual Meeting ISMRM-ESMRMB 2018.


Cite as: https://hdl.handle.net/21.11116/0000-0001-7E35-7
Abstract
An MRI-compatible robotic arm was developed to provide a precise fiber positioning for optogenetic fMRI of the rat brain. Corpus callosum connects two hemispheres through a thin sheet of spreading fiber bundle with only a few hundred micron thickness in the brain. This work shows that MgRA can guide fiber optic to precisely target the callosal fiber bundles. The optogenetically driven callosal axonal fiber-mediated neural activity leads to strong antidromic activation in the hemisphere with callosal neurons expressing ChR2 by fMRI.