Simulation of 13C labeling Effects of Glutamate and Glutamine in 1H MR Spectra 
with different Pulse Sequences at 9.4 T

Ziegs, T; Henning, A

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Simulation of 13C labeling Effects of Glutamate and Glutamine in 1H MR Spectra with different Pulse Sequences at 9.4 T

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Ziegs, T
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Henning, A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Ziegs, T., & Henning, A. (2018). Simulation of 13C labeling Effects of Glutamate and Glutamine in 1H MR Spectra with different Pulse Sequences at 9.4 T. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

Cite as: https://hdl.handle.net/21.11116/0000-0001-7DB8-4

Abstract

Glutamate related metabolism can be measured considering the 13C labeling effects from an administered 13C labeled substrate in pure 1H MRS spectra without a 13C channel. In this work, simulated 1H MRS spectra with FID, semi-Laser, and two PRESS sequences have been compared to optimize spectral resolution for glutamate and glutamine measurements at 9.4 T. Furthermore, spectral changes according to a two-compartment model were analyzed. As a result, this work indicates the fastest possible acquisition can be obtained with an FID sequence, while the best resolution possible can be obtained with a PRESS sequence.