Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein 
Triggered by AMPA and NMDA Receptor Stimulation

Kobayashi, Shunsuke; Tanaka, Toru; Soeda, Yoshiyuki; Almeida, Osborne F. X.; Takashima, Akihiko

doi:10.1016/j.ebiom.2017.05.012

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Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation

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Almeida, Osborne F. X.
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Kobayashi, S., Tanaka, T., Soeda, Y., Almeida, O. F. X., & Takashima, A. (2017). Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation. EBIOMEDICINE, 20, 120-126. doi:10.1016/j.ebiom.2017.05.012.

Cite as: https://hdl.handle.net/21.11116/0000-0001-958A-B

Abstract

Tau is a major component of the neurofibrillary tangles (NFT) that represent a pathological hallmark of Alzheimer's disease (AD). Although generally considered an axonal protein, Tau is found in the somato-dendritic compartment of degenerating neurons and this redistribution is thought to be a trigger of neurodegeneration in AD. Here, we show the presence of tau mRNA in a dendritic ribonucleoprotein (RNP) complex that includes Ca2(+)-calmodulin dependent protein kinase (CaMK)II alpha mRNA and that is translated locally in response to glutamate stimulation. Further, we show that TaumRNA is a component of mRNP granules that contain RNA-binding proteins, and that it interacts with Myosin Va, a postsynaptic motor protein; these findings suggest that tau mRNA is transported into dendritic spines. We also report that tau mRNA localized in the somato-dendritic component of primary hippocampal cells and that a sub-toxic concentration of glutamate enhances local translation and hyperphosphorylation of tau, effects that are blocked by the gluatamatergic antagonists MK801 and NBQX. These data thus demonstrate that alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) stimulation redistributes tau to the somato-dendritic region of neurons where it may trigger neurodegeneration. (C) 2017 The Authors. Published by Elsevier B.V.