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Journal Article

Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells

MPS-Authors
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Riesenberg,  Stephan
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Maricic,  Tomislav
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Riesenberg_Targeted_NatComm_2018.pdf
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Citation

Riesenberg, S., & Maricic, T. (2018). Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells. Nature Communications, 9(1): 2164. doi:10.1038/s41467-018-04609-7.


Cite as: https://hdl.handle.net/21.11116/0000-0001-6A92-3
Abstract
Small molecule inhibitors can influence the choice of repair pathways, enhancing nucleotide substitution and gene integration in CRISPR-mediated genome editing. Here the authors introduce CRISPY, a mix of small molecules that can enhance precise editing with Cpf1 and Cas9D10A in hiPSCs.