Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Integrative analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB)

MPG-Autoren
/persons/resource/persons224528

Yim,  Annie
Habermann, Bianca / Computational Biology, Max Planck Institute of Biochemistry, Max Planck Society;

/persons/resource/persons101406

Habermann,  Bianca
Habermann, Bianca / Computational Biology, Max Planck Institute of Biochemistry, Max Planck Society;

Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)

Krempel.pdf
(Verlagsversion), 2MB

Ergänzendes Material (frei zugänglich)

10_1186_s12859-018-2157-7.zip
(Ergänzendes Material), 6MB

Zitation

Krempel, R., Kulkarni, P., Yim, A., Lang, U., Habermann, B., & Frommolt, P. (2018). Integrative analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB). BMC Bioinformatics, 19: 156. doi:10.1186/s12859-018-2157-7.


Zitierlink: https://hdl.handle.net/21.11116/0000-0001-DCA3-F
Zusammenfassung
Background: Recent cancer genome studies on many human cancer types have relied on multiple molecular high-throughput technologies. Given the vast amount of data that has been generated, there are surprisingly few databases which facilitate access to these data and make them available for flexible analysis queries in the broad research community. If used in their entirety and provided at a high structural level, these data can be directed into constantly increasing databases which bear an enormous potential to serve as a basis for machine learning technologies with the goal to support research and healthcare with predictions of clinically relevant traits. Results: We have developed the Cancer Systems Biology Database (CancerSysDB), a resource for highly flexible queries and analysis of cancer-related data across multiple data types and multiple studies. The CancerSysDB can be adopted by any center for the organization of their locally acquired data and its integration with publicly available data from multiple studies. A publicly available main instance of the CancerSysDB can be used to obtain highly flexible queries across multiple data types as shown by highly relevant use cases. In addition, we demonstrate how the CancerSysDB can be used for predictive cancer classification based on whole-exome data from 9091 patients in The Cancer Genome Atlas (TCGA) research network. Conclusions: Our database bears the potential to be used for large-scale integrative queries and predictive analytics of clinically relevant traits.