Why do proteases mess up with antigen presentation by re-shuffling antigen 
sequences?

Liepe, J.; Ovaa, H.; Mishto, M.

doi:10.1016/j.coi.2018.04.016

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Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?

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Liepe, J.
Research Group of Quantitative and System Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Liepe, J., Ovaa, H., & Mishto, M. (2018). Why do proteases mess up with antigen presentation by re-shuffling antigen sequences? Current Opinion in Immunology, 52, 81-86. doi:10.1016/j.coi.2018.04.016.

Cite as: https://hdl.handle.net/21.11116/0000-0001-44ED-8

Abstract

The sequence of a large number of MHC-presented epitopes is not present as such in the original antigen because it has been re-shuffled by the proteasome or other proteases. Why do proteases throw a spanner in the works of our model of antigen tagging and immune recognition? We describe in this review what we know about the immunological relevance of post-translationally spliced epitopes and why proteases seem to have a second (dark) personality, which is keen to create new peptide bonds.