Voltage-dependence of drug-induced conductance in frog neuromuscular junction

Neher, Erwin; Sakmann, Bert

doi:10.1073/pnas.72.6.2140

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Voltage-dependence of drug-induced conductance in frog neuromuscular junction

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Sakmann, Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Neher, E., & Sakmann, B. (1975). Voltage-dependence of drug-induced conductance in frog neuromuscular junction. Proceedings of the National Academy of Sciences of the United States of America, 72(6), 2140-2144. doi:10.1073/pnas.72.6.2140.

Cite as: https://hdl.handle.net/21.11116/0000-0001-2F0B-0

Abstract

Membrane currents from voltage-clamped frog muscle fibers were recorded during iontophoretic application of steady doses of carbachol, acetylcholine, and suberyldicholine to the endplate region. In the presence of these drugs, an exponentially relaxing current was observed after step changes of membrane potential. The time constant of relaxation was found to be voltage-dependent. It was equal to the time constant obtained from the autocorrelation function of drug-induced conductance fluctuations measured under similar conditions. Analysis of instantaneous current at the on- and offsets of voltageclamp pulses showed that there is no shift in equilibrium potential during the pulses.