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Book Chapter

Possible role of parotid adrenergic beta-receptors in sialadenosis

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Witzemann,  Veit
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society;
Molecular anatomy of the neuromuscular junction, Max Planck Institute for Medical Research, Max Planck Society;
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Arglebe, C., Chilla, R., & Witzemann, V. (1980). Possible role of parotid adrenergic beta-receptors in sialadenosis. In Advances in Physiological Sciences (pp. 335-340). doi:10.1016/B978-0-08-027349-5.50053-7.


Cite as: https://hdl.handle.net/21.11116/0000-0001-1B2E-F
Abstract
This chapter discusses the behavior of beta-adrenoceptors in various nontumorous diseases of the cephalic salivary glands, such as sialadenosis, chronic-recurrent sialadenitis, and myoepithelial sialadenitis. Sialadenosis is a noninflammatory disease mainly of the parotid gland. It is clinically characterized by a diffuse bilateral swelling of the parotid gland, giving the face a hamster-like appearance. In one of the experiments described in the chapter, three human sialadenoses were tested. There was a distinct increase in beta-adrenoceptor concentration, suggesting involvement in sialadenosis of acinar cell denervation. A comparable increase in beta-adrenoceptors was also found in five cases of sialadenitis and was again accompanied by low amylase levels. Destruction of vegetative nerve terminals by inflammation could have caused denervation of acinar cells. Contamination of membrane fragments from acinar cells with membranes of inflammation cells could have simulated the effect of acinar cell denervation.