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Physical exercise and spatial training: A longitudinal study of effects on cognition, growth factors, and hippocampal plasticity

MPS-Authors
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Woost,  Luise
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Bazin,  Pierre-Louis
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Social Brain Laboratory, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands;
Spinoza Centre for Neuroimaging, University of Amsterdam, the Netherlands;

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Taubert,  Marco
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Sport Sciences, Faculty of Humanities, Otto von Guericke University Magdeburg, Germany;
Center for Behavioral Brain Sciences, Magdeburg, Germany;

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Trampel,  Robert
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Tardif,  Christine
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada;
Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada;

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Ott,  Derek V. M.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Epilepsy Center Berlin-Brandenburg, Germany;

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Rjosk,  Viola
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Obrig,  Hellmuth
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Center for Stroke Research, Charité University Medicine Berlin, Germany;

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Roggenhofer,  Elisabeth
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Clinical Neurosciences, University Hospital of Geneva, Switzerland;

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Klein,  Tilmann A.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Institute of Psychology, Otto von Guericke University Magdeburg, Germany;

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Citation

Woost, L., Bazin, P.-L., Taubert, M., Trampel, R., Tardif, C., Garthe, A., et al. (2018). Physical exercise and spatial training: A longitudinal study of effects on cognition, growth factors, and hippocampal plasticity. Scientific Reports, 8: 4239. doi:10.1038/s41598-018-19993-9.


Cite as: https://hdl.handle.net/21.11116/0000-0000-F417-3
Abstract
Physical exercise has been suggested to improve cognitive performance through various neurobiological mechanisms, mediated by growth factors such as BDNF, IGF-I, and VEGF. Moreover, animal research has demonstrated that combined physical and cognitive stimulation leads to increased adult neurogenesis as compared to either experimental condition alone. In the present study, we therefore investigated whether a sequential combination of physical and spatial training in young, healthy adults elicits an additive effect on training and transfer gains. To this end, we compared the effects of (i) eight 20-minute sessions of cycling, (ii) sixteen 30-minute sessions of spatial training, (iii) a combination of both, and included (iv) a passive control cohort. We assessed longitudinal changes in cognitive performance, growth factor levels, and T1 relaxation of hippocampal subfields (acquired with 7 T MRI). While substantial physical and spatial training gains were elicited in all trained groups, longitudinal transfer changes did not differ between these groups. Notably, we found no evidence for an additive effect of sequential physical and spatial training. These results challenge the extrapolation from the findings reported in animals to young, healthy adults.