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Journal Article

Characterisation of P. falciparum antigenic determinants isolated from a genomic expression library by differential antibody screening

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Koenen,  Michael
Molecular anatomy of the neuromuscular junction, Max Planck Institute for Medical Research, Max Planck Society;
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society;
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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https://academic.oup.com/nar/article-pdf/13/11/4191/6304854/13-11-4191.pdf
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https://doi.org/10.1093/nar/13.11.4191
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Citation

Langsley, G., Scherf, A., Mercereau−Puijalon, O., Koenen, M., Kahane, B., Mattei, D., et al. (1985). Characterisation of P. falciparum antigenic determinants isolated from a genomic expression library by differential antibody screening. Nucleic Acids Research (London), 13(11), 4191-4202. doi:10.1093/nar/13.11.4191.


Cite as: https://hdl.handle.net/21.11116/0000-0000-CF0C-B
Abstract
A genomic expression library of P.falciparum has been differentially screened with a number of immune sera. The response of 9 clones to the various sera is presented, together with the DNA sequence encoding the epitopes. All but one clone are extremely A+T rich and unlike the other P.falciparum epitopes described, are not composed of amino acid repeats. One clone, which responds specifically with a protective serum, has been analysed in detail. The epitope is carried on a 160kd antigen which is transcribed from a single gene to give a protein expressed in all of the erythrocytic forms. DNA sequence of this clone reveals it to have more than one open reading frame, only one of which is transcribed in the blood stages. The possible significance of the other open readings frames is discussed.