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Journal Article

Differential regulation of muscle acetylcholine receptor γ-and ϵ-subunit mRNAs

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/persons/resource/persons95970

Witzemann,  Veit
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Working Group Witzemann / Koenen, Max Planck Institute for Medical Research, Max Planck Society;
Molecular anatomy of the neuromuscular junction, Max Planck Institute for Medical Research, Max Planck Society;
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons95089

Sakmann,  Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

https://www.sciencedirect.com/science/article/pii/0014579387805185/pdf?md5=683fe51726392663ab8a2f6266b85746&pid=1-s2.0-0014579387805185-main.pdf
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https://doi.org/10.1016/0014-5793(87)80518-5
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Citation

Witzemann, V., Barg, B., Nishikawa, Y., Sakmann, B., & Numa, S. (1987). Differential regulation of muscle acetylcholine receptor γ-and ϵ-subunit mRNAs. FEBS Letters, 223(1), 104-112. doi:10.1016/0014-5793(87)80518-5.


Cite as: https://hdl.handle.net/21.11116/0000-0000-C774-D
Abstract
The contents of the mRNAs encoding the γ- and ϵ-subunits of the nicotinic acetylcholine receptor as well as the single-channel properties of the receptor have been assessed in innervated, denervated and reinnervated rat muscle. The changes in abundance of the γ- and ϵ-subunit mRNAs correlate with the changes in relative density of two classes of acetylcholine receptor channels. The results support the view that a switch in the relative abundance of the γ- and ϵ-subunit mRNAs is a major mechanism in regulating the properties of acetylcholine receptor channels in muscle.