Rupestrines A-D, alkaloids from the aerial parts of Corydalis rupestris

Naseri, M.; Emami, S. A.; Asili, J.; Tayarani-Najaran, Z.; Dehghan, G.; Schneider, Bernd; Iranshahi, M.

doi:10.1016/j.bioorg.2018.02.019

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Rupestrines A-D, alkaloids from the aerial parts of Corydalis rupestris

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Schneider, Bernd
Research Group Biosynthesis / NMR, MPI for Chemical Ecology, Max Planck Society;

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引用

Naseri, M., Emami, S. A., Asili, J., Tayarani-Najaran, Z., Dehghan, G., Schneider, B., & Iranshahi, M. (in press). Rupestrines A-D, alkaloids from the aerial parts of Corydalis rupestris. Bioorganic Chemistry. doi:10.1016/j.bioorg.2018.02.019.

引用: https://hdl.handle.net/21.11116/0000-0000-8473-9

要旨

Phytochemical investigation of the dichloromethane extract of the dried aerial parts of Corydalis rupestris (Papaveraceae) resulted in the identification of four new isoquinoline alkaloids rupestrines A-D and one known isoquinoline alkaloid, namely, stylopine. The structures of these compounds were characterized by extensive spectroscopic methods including 1D- (1H and 13C) and 2D NMR experiments (COSY, HSQC, HMBC, and NOESY) as well as HRESIMS analyses. In addition, the absolute configurations of rupestrines A-D were determined using modified Mosher’s method. Cytotoxic effects of alkaloids and their interaction with albumin were also investigated in this study. Phytochemical investigation of the dichloromethane extract of the dried aerial parts of Corydalis rupestris resulted in four new isoquinoline alkaloids rupestrines A- D and one known isoquinoline alkaloid, stylopine.