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Journal Article

The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

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Blin,  Kai
Dieterich – Computational RNA Biology and Ageing, Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Medema,  Marnix H.
Microbial Genomics Group, Department of Molecular Ecology, Max Planck Institute for Marine Microbiology, Max Planck Society;

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Kottmann,  Renzo
Microbial Genomics Group, Department of Molecular Ecology, Max Planck Institute for Marine Microbiology, Max Planck Society;

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Citation

Blin, K., Medema, M. H., Kottmann, R., Lee, S. Y., & Weber, T. (2017). The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters. NUCLEIC ACIDS RESEARCH, 45(D1), D555-D559. doi:10.1093/nar/gkw960.


Abstract
Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms. Therefore, we developed the antiSMASH database, a simple but highly useful new resource to browse antiSMASH-annotated BGCs in the currently 3907 bacterial genomes in the database and perform advanced search queries combining multiple search criteria. antiSMASH-DB is available at http://antismash-db.secondarymetabolites.org/.