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Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder

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Henning,  A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Hock, A., Ernst, J., Henning, A., Seifritz, E., Boeker, H., & Grimm, S. (2016). Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder. Poster presented at 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.


Cite as: https://hdl.handle.net/21.11116/0000-0000-7B9B-8
Abstract
Proton magnetic resonance spectroscopy (1H-MRS) was used to test whether patients with major depressive disorder have increased glucose and lactate levels in the pregenual anterior cingulate cortex (PACC) compared to healthy controls. Therefore, forty healthy and depressed participants spectra were acquired from the PACC using a maximum echo JPRESS protocol. Results show significant increases of glucose and lactate in patients, which are also associated with depression severity. These findings indicate impaired brain energy metabolism in MDD with increased fraction of energy utilization via glycolysis and reduced mitochondrial oxidative clearance of lactate.