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Fast and efficient free induction decay MRSI at 9.4 T: assessment of neuronal activation-related changes in the human brain biochemistry

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Chadzynski,  GL
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Bause,  J
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Shajan,  G
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Dept. Empirical Inference, Max Planck Institute for Intelligent Systems, Max Planck Society;

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Scheffler,  K
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Ehses,  P
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Chadzynski, G., Bause, J., Shajan, G., Pohmann, R., Scheffler, K., & Ehses, P. (2016). Fast and efficient free induction decay MRSI at 9.4 T: assessment of neuronal activation-related changes in the human brain biochemistry. Poster presented at 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.


Cite as: https://hdl.handle.net/21.11116/0000-0000-7B99-A
Abstract
The aim was to design a MRSI-FID sequence for ultra-high field applications with high acquisition speed and sampling efficiency. The sequence allows acquisition of a 32×32 voxel matrix within approximately 2 min, down to 30 sec using parallel imaging. We have examined the suitability of this approach for assessing biochemical changes in the human visual cortex during a visual stimulus. Obtained results were in accordance with other functional MRS studies and indicate that the developed sequence is suitable for rapid monitoring of stimulus evoked changes in human brain biochemistry at a very high spatial resolution.