The murine NPY-1 receptor gene. Structure and delineation of tissue-specific 
expression

Eva, Carola; Oberto, Alessandra; Sprengel, Rolf; Genazzani, Enrico

doi:10.1016/0014-5793(92)81490-D

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The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression

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Sprengel, Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society;
Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Eva, C., Oberto, A., Sprengel, R., & Genazzani, E. (1992). The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression. FEBS Letters, 314(3), 285-288. doi:10.1016/0014-5793(92)81490-D.

Cite as: https://hdl.handle.net/21.11116/0000-0000-5E43-C

Abstract

The murine gene for the NPY-1 receptor subtype for neuropeptide Y was characterized by DNA sequencing and expression studies. It comprises three exons with a 6,400 bp 5'-untranslated and a 80 bp internal intronic sequence. The 5'-flanking region of this gene lacks TATA or CCAAT consensus sequences in the proximity to the multiple transcription initiation sites. A 1,300 bp genomic fragment of the 5'-flanking region drives the expression of the lacZ reporter gene in NG108-15 cells and primary cultured neurons but not in glial and human embryonic kidney cells. In addition, it contains consensus sequences for various transcription factors including cAMP- and glucocorticoid-responsive elements.