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Journal Article

Two possible modes of pioneering associated with combination of H2A.Z and p300/CBP at nucleosome-occupied enhancers

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Cauchy,  Pierre
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Koch,  Frederic
Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Cauchy, P., Koch, F., & Andrau, J.-C. (2017). Two possible modes of pioneering associated with combination of H2A.Z and p300/CBP at nucleosome-occupied enhancers. Transcription, 8, 179-184. doi:10.1080/21541264.2017.1291395.


Cite as: https://hdl.handle.net/21.11116/0000-0000-C15B-0
Abstract
Pioneer transcription factors are defined by their ability to bind nucleosome-occupied regions. Here, we discuss the properties of nucleosomes bound by pioneers at enhancer regions. We describe how select pioneers bind nucleosome-occupied or -depleted enhancer sites. Importantly, by revisiting and expanding existing data sets, we show differential H2A.Z and p300/CBP association at bound enhancers, highlighting two possible pioneering modes.