Products of cytochrome P450(BioI) (CYP107H1)-catalyzed oxidation of fatty acids.

Cryle, Max; Matovic, Nicholas J.; De Voss, James J.

doi:10.1021/ol035254e

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Products of cytochrome P450(BioI) (CYP107H1)-catalyzed oxidation of fatty acids.

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Cryle, Max
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;
Cytochrome P450, Max Planck Institute for Medical Research, Max Planck Society;
Heme and Flavin Enzymes, Max Planck Institute for Medical Research, Max Planck Society;

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http://pubs.acs.org/doi/pdf/10.1021/ol035254e
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http://pubs.acs.org/doi/suppl/10.1021/ol035254e/suppl_file/ol035254esi20030801_035147.pdf
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https://doi.org/10.1021/ol035254e
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Citation

Cryle, M., Matovic, N. J., & De Voss, J. J. (2003). Products of cytochrome P450(BioI) (CYP107H1)-catalyzed oxidation of fatty acids. Organic Letters, 5(18), 3341-3344. doi:10.1021/ol035254e.

Cite as: https://hdl.handle.net/21.11116/0000-0000-3BF2-D

Abstract

Oxidation of tetradecanoic and hexadecanoic acids by cytochrome P450(BioI) (CYP107H1) produces mainly the 11-, 12-, and 13-hydroxy C(14) fatty acids and the 11- to 15-hydroxy C(16) fatty acids, respectively. In contrast to previous reports, terminal hydroxylation is not observed. The enantiospecificity of fatty acid hydroxylation by P450(BioI) was also determined, and the enzyme was shown to be moderately selective for production of the (R)-alcohols.