18F‑Deoxyfluorination of Phenols via Ru π‑Complexes

Beyzavi, M. Hassan; Mandal, Debashis; Strebl, Martin G.; Neumann, Constanze N.; D'Amato, Erica M.; Chen, Junting; Hooker, Jacob M.; Ritter, Tobias

doi:10.1021/acscentsci.7b00195

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¹⁸F‑Deoxyfluorination of Phenols via Ru π‑Complexes

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Chen, Junting
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Ritter, Tobias
Department of Chemistry and Chemical Biology, Harvard University;
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital;

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Citation

Beyzavi, M. H., Mandal, D., Strebl, M. G., Neumann, C. N., D'Amato, E. M., Chen, J., et al. (2017). ¹⁸F‑Deoxyfluorination of Phenols via Ru π‑Complexes. ACS Central Science, 3(9), 944-948. doi:10.1021/acscentsci.7b00195.

Cite as: https://hdl.handle.net/21.11116/0000-0000-77A1-4

Abstract

The deficiency of robust and practical methods for ¹⁸F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted ¹⁸F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging.