English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  DetailsSummary

Released
Journal Article

Neural progenitor cell polarity and cortical development

MPS-Authors
/persons/resource/persons213743

Taverna,  Elena
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Arai_Neural_FrontCellNeuSci_2017.pdf
(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Arai, Y., & Taverna, E. (2017). Neural progenitor cell polarity and cortical development. Frontiers in Cellular Neuroscience, 11: 384. doi:10.3389/fncel.2017.00384.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002E-9775-0
Abstract
Neurons populating the cerebral cortex are generated during embryonic development from neural stem and progenitor cells in a process called neurogenesis. Neural stem and progenitor cells are classified into several classes based on the different location of mitosis (apical or basal) and polarity features (bipolar, monopolar and non-polar). The polarized architecture of stem cells is linked to the asymmetric localization of proteins, mRNAs and organelles, such as the centrosome and the Golgi apparatus. Polarity affects stem cell function and allows stem cells to integrate environmental cues from distinct niches in the developing cerebral cortex. The crucial role of polarity in neural stem and progenitor cells is highlighted by the fact that impairment of cell polarity is linked to neurodevelopmental disorders such as Down syndrome, Fragile X syndrome, autism spectrum disorders and schizophrenia.