Ancillary Activity: Beyond Core Metabolism in Immune Cells

Puleston, Daniel J.; Villa, Matteo; Pearce, Erika L.

doi:10.1016/j.cmet.2017.06.019

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Ancillary Activity: Beyond Core Metabolism in Immune Cells

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Puleston, Daniel J.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;
Nuffield Department of Orthopedics, Rheumatology, and Musculoskeletal Diseases, The Kennedy Institute of Rheumatology, University of Oxford;

Villa, Matteo
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Pearce, Erika L.
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Puleston, D. J., Villa, M., & Pearce, E. L. (2017). Ancillary Activity: Beyond Core Metabolism in Immune Cells. Cell Metabolism, 131-141. doi:10.1016/j.cmet.2017.06.019.

Cite as: https://hdl.handle.net/21.11116/0000-0000-BF69-4

Abstract

Immune cell function and fate are intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is less well understood. Here we survey the literature and highlight recent advances in our understanding of several ancillary metabolic pathways and how they support processes beyond ATP production and ultimately contribute to protective immunity.