English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONS
  This item is discarded!DetailsSummary

Discarded

Journal Article

Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci

MPS-Authors
/persons/resource/persons15991

Wang,  J.
Department of Biochemistry and Cell Biology, MPI for biophysical chemistry, Max Planck Society;
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany; Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, Kiel, Germany; Norwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, University Hospital Rikshospitalet, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany; Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Internal Medicine I, University Hospital S.-H. (UKSH, Campus Kiel), Kiel, Germany;

/persons/resource/persons28295

Lieb,  W.
MPI for Extraterrestrial Physics, Max Planck Society;
High Energy Astrophysics, MPI for Extraterrestrial Physics, Max Planck Society;
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany; Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, Kiel, Germany; Norwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, University Hospital Rikshospitalet, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany; Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Internal Medicine I, University Hospital S.-H. (UKSH, Campus Kiel), Kiel, Germany;

External Resource

(No access)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Rühlemann, M., Degenhardt, F., Thingholm, L., Wang, J., Skiecevičienė, J., Rausch, P., et al. (2017). Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci. Gut Microbes, 1-8. doi:10.1080/19490976.2017.1356979.


Abstract
Factors shaping the human intestinal microbiota range from environmental influences, like smoking and exercise, over dietary patterns and disease to the host's genetic variation. Recently, we could show in a microbiome genome-wide association study (mGWAS) targeting genetic variation influencing the β diversity of gut microbial communities, that approximately 10 of the overall gut microbiome variation can be explained by host genetics. Here, we report on the application of a new method for genotype-β-diversity association testing, the distance-based F (DBF) test. With this we identified 4 loci with genome-wide significant associations, harboring the genes CBEP4, SLC9A8, TNFSF4, and SP140, respectively. Our findings highlight the utility of the high-performance DBF test in β diversity GWAS and emphasize the important role of host genetics and immunity in shaping the human intestinal microbiota. © 2017 The Author(s). Published with license by Taylor Francis