Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Modeling the contributions of chromosome segregation errors and aneuploidy to Saccharomyces hybrid sterility

MPG-Autoren
/persons/resource/persons134762

Boynton,  Primrose J.
Max-Planck Research Group Experimental Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society;

/persons/resource/persons182899

Janzen,  Thijs
Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society;

Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Boynton, P. J., Janzen, T., & Greig, D. (2017). Modeling the contributions of chromosome segregation errors and aneuploidy to Saccharomyces hybrid sterility. Yeast. doi:10.1002/yea.3282.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002E-584E-5
Zusammenfassung
Errors in meiosis can be important postzygotic barriers between different species. In Saccharomyces hybrids, chromosomal missegregation during meiosis I produces gametes with missing or extra chromosomes. Gametes with missing chromosomes are inviable, but we do not understand how extra chromosomes (disomies) influence hybrid gamete inviability. We designed a model predicting rates of missegregation in interspecific hybrid meioses assuming several different mechanisms of disomy tolerance, and compared predictions from the model with observations of sterility in hybrids between Saccharomyces yeast species. Sterility observations were consistent with the hypothesis that chromosomal missegregation causes hybrid sterility, and the model indicated that missegregation probabilities of 13-50 per chromosome can cause observed values of 90-99 hybrid sterility regardless of how cells tolerate disomies. Missing chromosomes in gametes are responsible for most infertility, but disomies may kill as many as 11 of the gametes produced by hybrids between Saccharomyces cerevisiae and Saccharomyces paradoxus. © 2017 John Wiley Sons, Ltd.