The intestinal microbiota determines the colitis-inducing potential of 
T-bet-deficient Th cells in mice

Zimmermann, Jakob; Durek, Pawel; Kühl, Anja A.; Schattenberg, Florian; Maschmeyer, Patrick; Siracusa, Francesco; Lehmann, Katrin; Westendorf, Kerstin; Weber, Melanie; Riedel, René; Müller, Susann; Radbruch, Andreas; Chang, Hyun-Dong

doi:10.1002/eji.201747100

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The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice

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Riedel, René
Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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http://onlinelibrary.wiley.com/doi/10.1002/eji.201747100/full
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Citation

Zimmermann, J., Durek, P., Kühl, A. A., Schattenberg, F., Maschmeyer, P., Siracusa, F., et al. (2017). The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice. European Journal of Immunology, 0. doi:10.1002/eji.201747100.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002E-2DF5-6

Abstract

Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag-/- mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag-/- recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation. © 2017 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.