De novo synaptogenesis induced by GABA in the developing mouse cortex

Oh, Won Chan; Lutzu, Stefano; Castillo, Pablo E.; Kwon, Hyung-Bae

doi:10.1126/science.aaf5206

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学術論文

De novo synaptogenesis induced by GABA in the developing mouse cortex

MPS-Authors

Oh, Won Chan
Max Planck Florida Institute for Neuroscience, Max Planck Society;

Kwon, Hyung-Bae
Max Planck Florida Institute for Neuroscience, Max Planck Society;
MPI of Neurobiology, Max Planck Society;

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引用

Oh, W. C., Lutzu, S., Castillo, P. E., & Kwon, H.-B. (2016). De novo synaptogenesis induced by GABA in the developing mouse cortex. Science (New York, N.Y.), 353(6303), 1037-1040. doi:10.1126/science.aaf5206.

引用: https://hdl.handle.net/11858/00-001M-0000-002E-2C85-8

要旨

Dendrites of cortical pyramidal neurons contain intermingled excitatory and inhibitory synapses. Here we study the local mechanisms that regulate the formation and distribution of synapses. We show that local γ-aminobutyric acid (GABA) release on dendrites of mouse cortical layer 2/3 pyramidal neurons can induce gephyrin puncta and dendritic spine formation via GABAA receptor activation and voltage-gated calcium channels during early postnatal development. Furthermore, the newly formed inhibitory and excitatory synaptic structures rapidly gain functions. Bidirectional manipulation of GABA release from somatostatin-positive interneurons increased and decreased the number of gephyrin puncta and dendritic spines, respectively. These results highlight a non-canonical function of GABA as a local synaptogenic element shaping the early establishment of neuronal circuitry in mouse cortex.