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Integrated flow processing — challenges in continuous multistep synthesis

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Pieber,  Bartholomäus
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Gilmore,  Kerry
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Seeberger,  Peter H.
Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Pieber, B., Gilmore, K., & Seeberger, P. H. (2017). Integrated flow processing — challenges in continuous multistep synthesis. Journal of Flow Chemistry. doi:10.1556/1846.2017.00016.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002E-1E73-0
Abstract
The way organic multistep synthesis is performed is changing due to the adoption of flow chemical techniques, which has enabled the development of improved methods to make complex molecules. The modular nature of the technique provides not only access to target molecules via linear flow approaches but also for the targeting of structural cores with single systems. This perspective article summarizes the state of the art of continuous multistep synthesis and discusses the main challenges and opportunities in this area.