Heterogeneity of biotransformation of fluoranthene in perifused liver cells.

Stier, A.; Schlenker, A.; Sidhu, J.; Kühnle, W.; Finch, S.A.E.

doi:10.1007/BF00390484

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Heterogeneity of biotransformation of fluoranthene in perifused liver cells.

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Stier, A.
Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society;

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Kühnle, W.
Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society;

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Finch, S.A.E.
Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Stier, A., Schlenker, A., Sidhu, J., Kühnle, W., & Finch, S. (1988). Heterogeneity of biotransformation of fluoranthene in perifused liver cells. Journal of Cancer Research and Clinical Oncology, 114(1), 39-46. doi:10.1007/BF00390484.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-F3B7-9

Abstract

Pathways of biotransformation of the carcinogenic polycyclic hydrocarbon fluoranthene in individual isolated perifused liver cells were delineated using noninvasive microfluorescence spectroscopic techniques. An example of heterogeneity of coupling between phase I and phase II enzymes detected in a population of β-naphthoflavone-induced rat liver cells demonstrates the usefulness of the experimental model of perifused liver cells.