English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  DetailsSummary

Released
Journal Article

Protein homeostasis and synaptic plasticity

MPS-Authors
/persons/resource/persons207914

Cajigas,  I. J.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

/persons/resource/persons208278

Will,  T.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

/persons/resource/persons208206

Schuman,  E. M.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Cajigas, I. J., Will, T., & Schuman, E. M. (2010). Protein homeostasis and synaptic plasticity. The EMBO Journal, 29(16), 2746-2752.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002E-2171-1
Abstract
It is clear that de novo protein synthesis has an important function in synaptic transmission and plasticity. A substantial amount of work has shown that mRNA translation in the hippocampus is spatially controlled and that dendritic protein synthesis is required for different forms of long-term synaptic plasticity. More recently, several studies have highlighted a function for protein degradation by the ubiquitin proteasome system in synaptic plasticity. These observations suggest that changes in synaptic transmission involve extensive regulation of the synaptic proteome. Here, we review experimental data supporting the idea that protein homeostasis is a regulatory motif for synaptic plasticity. The EMBO Journal (2010) 29, 2746-2752. doi:10.1038/emboj.2010.173