GABA signaling stimulates α-cell-mediated β-like cell neogenesis.

Napolitano, T.; Avolio, F.; Vieira, A.; Ben-Othmann, N.; Courtney, M.; Gjernes, E.; Hadzic, B.; Druelle, N.; Navarro Sanz, S.; Silvano, S.; Mansouri, A.; Collombat, P.

doi:10.1080/19420889.2017.1300215

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GABA signaling stimulates α-cell-mediated β-like cell neogenesis.

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Mansouri, A.
Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society;

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Citation

Napolitano, T., Avolio, F., Vieira, A., Ben-Othmann, N., Courtney, M., Gjernes, E., et al. (2017). GABA signaling stimulates α-cell-mediated β-like cell neogenesis. Communicative and Integrative Biology, 10: e1300215. doi:10.1080/19420889.2017.1300215.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-B168-9

Abstract

Diabetes is a chronic and progressing disease, the number of patients increasing exponentially, especially in industrialized countries. Regenerating lost insulin-producing cells would represent a promising therapeutic alternative for most diabetic patients. To this end, using the mouse as a model, we reported that GABA, a food supplement, could induce insulin-producing beta-like cell neogenesis offering an attractive and innovative approach for diabetes therapeutics.