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Journal Article

Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride

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Tredwell,  Mathew
University of Oxford, Chemistry Research laboratory, 12 Mansfield Road, OX1 3TA, Oxford, UK ;
Research Group Tredwell, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Verhoog, S., Pfeifer, L., Khotavivattana, T., Calderwood, S., Collier, T. L., Wheelhouse, K., et al. (2016). Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride. Synlett, 27(1), 25-28. doi:10.1055/s-0035-1560592.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-B100-4
Abstract
We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.