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The dental phenotype of hairless dogs with FOXI3 haploinsufficiency

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Kupczik,  Kornelius
Max Planck Weizmann Center for integrative Archaeology and Anthropology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Cagan,  Alexander
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Brauer,  Silke
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Kupczik_Dental_SciRep_2017.pdf
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Kupczik, K., Cagan, A., Brauer, S., & Fischer, M. S. (2017). The dental phenotype of hairless dogs with FOXI3 haploinsufficiency. Scientific Reports, 7: 5459. doi:10.1038/s41598-017-05764-5.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002D-9A17-E
Zusammenfassung
Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified this FOXI3 variant in a historical museum sample of pedigreed hairless dog skulls by using ancient DNA extraction and present the associated dental phenotype. Unlike in the coated wild type dogs, the hairless dogs were characterised in both the mandibular and maxillary dentition by a loss of the permanent canines, premolars and to some extent incisors. In addition, the deciduous fourth premolars and permanent first and second molars consistently lacked the distal and lingual cusps; this resulted in only a single enlarged cusp in the basin-like heel (talonid in lower molars, talon in upper molars). This molar phenotype is also found among several living and fossil carnivorans and the extinct order Creodonta in which it is associated with hypercarnivory. We therefore suggest that FOXI3 may generally be involved in dental (cusp) development within and across mammalian lineages including the hominids which are known to exhibit marked variability in the presence of lingual cusps.