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Journal Article

Aberrant long-range temporal correlations in depression are attenuated after psychological treatment

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Huntenburg,  Julia M.
Dahlem Institute for Neuroimaging of Emotion, FU Berlin, Germany;
Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Nikulin,  Vadim
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia;
Department of Neurology, Charité University Medicine Berlin, Germany;

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Citation

Gärtner, M., Irrmischer, M., Winnebeck, E., Fissler, M., Huntenburg, J. M., Schroeter, T., et al. (in press). Aberrant long-range temporal correlations in depression are attenuated after psychological treatment. Frontiers in Human Neuroscience.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-7560-4
Abstract
The spontaneous oscillatory activity in the human brain shows long-range temporal correlations (LRTC) that extend over time scales of seconds to minutes. Previous research has demonstrated aberrant LRTC in depressed patients; however, it is unknown whether the neuronal dynamics normalize after psychological treatment. In this study, we recorded EEG during eyes-closed rest in depressed patients (N = 71) and healthy controls (N = 25), and investigated the temporal dynamics in depressed patients at baseline, and after attending either a brief mindfulness training or a stress reduction training. Compared to the healthy controls, depressed patients showed stronger LRTC in theta oscillations (4 – 7 Hz) at baseline. Following the psychological interventions both groups of patients demonstrated reduced LRTC in the theta band. The reduction of theta LRTC differed marginally between the groups, and explorative analyses of separate groups revealed noteworthy topographic differences. A positive relationship between the changes in LRTC, and changes in depressive symptoms was observed in the mindfulness group. In summary, our data show that aberrant temporal dynamics of ongoing oscillations in depressive patients are attenuated after treatment, and thus may help uncover the mechanisms with which psychotherapeutic interventions affect the brain.