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Human organomics: A fresh approach to understanding human development using single-cell transcriptomics

MPG-Autoren
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Camp,  J. Gray
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Treutlein,  Barbara
Single Cell Genomics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Zitation

Camp, J. G., & Treutlein, B. (2017). Human organomics: A fresh approach to understanding human development using single-cell transcriptomics. Development, 144(9), 1584-1587. doi:10.1242/dev.150458.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002D-46EF-1
Zusammenfassung
Skip to Next Section Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these ‘organoids’ into constituent parts, and reconstruct lineage trajectories during cell differentiation. In this Spotlight article we summarize the different approaches to performing single-cell transcriptomics on organoids, and discuss the opportunities and challenges of applying these techniques to generate organ-level, mechanistic models of human development and disease. Together, these technologies will move past characterization to the prediction of human developmental and disease-related phenomena.