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Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants

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Ulaganathan,  Vijay K.
Ullrich, Axel / Molecular Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Ullrich,  Axel
Ullrich, Axel / Molecular Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Ulaganathan, V. K., & Ullrich, A. (2016). Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants. Molecular & Cellular Oncology, 3(3): e1145176. doi:10.1080/23723556.2016.1145176.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-3FA8-1
Abstract
In cancer biology, somatic mutations in the extracellular (ligand binding) and cytosolic (functional/catalytic) domains are pursued with great interest. However, in our recent publication we report that germline mutations in the membrane-proximal region of type I receptors are able to modulate the amplitude of signal transducer and activator of transcription 3 (STAT3) signaling in cells. This unexpected finding has implications for the prognosis of heritable cancer.