English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  DetailsSummary

Released
Journal Article

A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory

MPS-Authors
/persons/resource/persons138194

Carrillo Roa,  Tania
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80505

Sämann,  Philipp G.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80272

Binder,  Elisabeth B.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

ncomms15193.pdf
(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Freytag, V., Carrillo Roa, T., Milnik, A., Sämann, P. G., Vukojevic, V., Coynel, D., et al. (2017). A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory. NATURE COMMUNICATIONS, 8, 1-12.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-8418-8
Abstract
Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P = 3.86 x 10(-8)) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P < 0.001). A multilocus genetic score reflecting genetic variability of this signature is associated with memory performance (P = 0.0003) in 3,346 young and elderly healthy adults. The genomic location of the contributing methylation sites points to the involvement of specific immune system genes. The decomposition of blood methylome-wide patterns bears considerable potential for the study of brain-related traits.